Over time the regional viticulture has undergone various transformations due to changes in taste, and the consequent orientation of the market, as well as to the attacks of phylloxera and peronospera .Thus certain autochthonous wines such as Forgiarìn, Scjaglìn, Piculit neri, Ucelùt, Cjanorie, Piccola nera, have disappeared, or remain at the level of amateur cultivation, or experimental plants.

At the end of the nineteenth century experiments of hybridization between European and American species were also carried out, in particular with the Clintòn varieties, today completely abandoned (crossing between the Vitis labrusca and the Vitis riparia), Isabella or Fragolino grapes (Vitis labrusca, crossed with Vitis vinifera) and Noah or Noax also called white fragolino or white Clintòn (obtained by crossing a clone of Vitis labrusca with a clone of Vitis riparia). The wines obtained from these hybrids were, however, poor and not suitable for aging and rich in methanol. Furthermore, they were considered by the law “non-wines”, because they were not exclusively obtained from vitis vinifera, and for this reason they suffered severe penalties.

While Clintòn has almost disappeared, Fraglino and Noah are still being produced, even if not for commercial use.
Finally, among the now abandoned crossings, let us remember Bacò (a crossing of Vitis vinifera  and  Vitis riparia from France).